Insight into psychiatric disease and development of therapeutics relies on behavioral tasks that study similar cognitive constructs in multiple species. The reversal learning task is one popular paradigm that probes flexible behavior, aberrations of …
Nervous systems maintain information internally using persistent activity changes. The mechanisms by which this activity arises are incompletely understood. We study prefrontal cortex (PFC) in mice performing behaviors in which stimuli predicted …
We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane …